https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Senescence of IPF lung fibroblasts disrupt alveolar epithelial cell proliferation and promote migration in wound healing https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45148 Wed 26 Oct 2022 19:13:19 AEDT ]]> IL-33 Expression Is Lower in Current Smokers at Both Transcriptomic and Protein Level https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54312 Tue 20 Feb 2024 14:27:17 AEDT ]]> Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54219 ACTA2), collagen (COL) 1A1 and fibulin-1 (Fbln1) and higher Fbln1 protein deposition after 7 days. Our results show that exposure of lung fibroblasts to fibrotic stiffness activates genes and secreted factors that are part of fibrotic responses and part of the Senescence-associated secretory phenotype (SASP). This overlap may contribute to the creation of a feedback loop whereby fibroblasts create a perpetuating cycle reinforcing progression of a fibrotic response.]]> Tue 13 Feb 2024 11:58:49 AEDT ]]> Regulation of cellular senescence is independent from profibrotic fibroblast-deposited ECM https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48871 Thu 13 Apr 2023 12:47:57 AEST ]]> Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseases https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44052 Thu 06 Oct 2022 08:58:07 AEDT ]]>